Mark WJ Ferguson
+44 (0) 161 275 6775
have a long standing interest in the cellular and molecular
mechanisms underlying wound repair, specifically as they relate to
the biology of scarring and the pathogenesis of non-healing wounds,
such as venous ulcers, diabetic ulcers and pressure sores.
My Group have elucidated many of the cellular and molecular
mechanisms underlying scar free embryonic wound healing and utilised
this information to develop new therapeutic strategies to prevent
scarring during adult healing.
We have also discovered novel ways of accelerating the
healing of chronic wounds in both animals and man.
This research base relates to the ongoing work in the
Interdisciplinary Research Collaboration on Tissue Engineering in
several important ways. First,
we wish to improve the integration of tissue engineered grafts
within the host and to minimise scarring at this interface.
These approaches combine existing experimental data and
approaches in my group with novel strategies in tissue engineered
scaffolds. Second, we
have a major interest in how stem cells are recruited to and
differentiate in adult wounds.
This approach is being exploited within the IRCol to utilise
such primitive stem cells, both in in vitro manipulations and
transplantation as well as in in vivo recruitment to tissue
engineered constructs. Finally
we have a well developed clinical interface focusing on experimental
medicine. This allows
us to test any new approaches quickly in man as soon as it is
ethically possible to do so. We
intend to exploit this infrastructure and expertise to rapidly
investigate the benefits of any putative new tissue engineered
constructs or strategies, which we may develop in the IRCol.