Selected Recent Scientific Publications

Rhodes NP, Hunt JA, Longinotti C, Pavesio A. In vivo characterization of Hyalonect®, a novel biodegradable mesh. Journal of Surgical Research 2011 In Press.
doi:10.1016/j.jss.2010.09.015

Bryan N, Andrews K, Loughran MJ, Rhodes NP, Hunt JA. Elucidating the contribution of the elemental composition of fetal calf serum towards antigenic expression of primary human umbilical vein endothelial cells in vitro. Bioscience Reports 2011;31:199-210.
doi:10.1042/BSR20100064

Curran JM, Stokes R, Irvine E, Graham D, Amro NA, Sanedrin RG, Jamil H, Hunt JA. Introducing dip pen nanolithography as a tool for controlling stem cell behaviour: unlocking the potential of the next generation of smart materials in regenerative medicine. Lab on a Chip 2010;10:1662-70.
doi:10.1039/c004149a

Alves CM, Reis RL, Hunt JA. The dynamics, kinetics and reversibility of protein adsorption onto the surface of biodegradable materials. Soft Matter 2010;6:4135-43.
doi:10.1039/C002972F

Alves CM, Reis RL, Hunt JA. The competitive adsorption of human proteins onto natural-based biomaterials. Journal of the Royal Society Interface 2010;7:1367-77.
doi:10.1098/rsif.2010.0022

Pu F, Rhodes NP, Bayon Y, Chen R, Brans G, Benne R, Hunt JA. The use of flow perfusion culture and subcutaneous implantation with fibroblast-seeded PLLA-collagen 3D scaffolds for abdominal wall repair. Biomaterials 2010;31:4330-40.
doi:10.1016/j.biomaterials.2010.02.010

Curran JM, Chen R, Hunt JA. Material induced mesenchymal stem cell differentiation. Biomaterials 2010;31:1463-64.
doi:10.1016/j.biomaterials.2009.12.001

Donegan GC, Hunt JA, Rhodes NP. Investigating the importance of flow when utilizing hyaluronan scaffolds for tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 2010;4:83-95.
doi:10.1002/term.208
Curran JM, Chen R, Stokes R, Irvine E, Graham D, Gubbins E, Delaney D, Amro N, Sanedrin R, Jamil H, Hunt JA. Nanoscale definition of substrate materials to direct human adult stem cells towards tissue specific populations. Journal of Materials Science: Materials in Medicine 2010;21:1021.
doi:10.1007/s10856-009-3976-x
O'Hare P, Meenan BJ, Burke GA, Byrne G, Dowling D, Hunt JA. Biological responses to Hydroxyapatite surfaces deposited via a co-incident microblasting technique. Biomaterials 2010:31;515-22.
doi:10.1016/j.biomaterials.2009.09.067

Halfhide CP, Brearey SP, Flanagan BF, Hunt JA, Howarth D, Cummerson J, Edwards S, Hart CA, Smyth RL. Neutrophil TLR4 protein expression is reduced in the airways of infants with severe bronchiolitis. Thorax 2009;64:798-805.
doi:10.1136/thx.2008.107821

Curran JM, Tang Z, Hunt JA. PLGA doping of PCL affects the plastic potential of human mesenchymal stem cells, both in the presence and absence of biological stimuli. Journal of Biomedical Materials Research Part A 2009;89:1-12.
doi:10.1002/jbm.a.31966
Bryan N, Rhodes NP, Hunt JA. Derivation and performance of an entirely autologous injectable hydrogel delivery system for cell-based therapies. Biomaterials 2009;30;180-8.
doi:10.1016/j.biomaterials.2008.09.003
Rhodes NP, di Bartolo C, Bellini D, Hunt JA. Induction of adipose tissue regeneration by chemically-modified hyaluronic acid. International Journal of Nano and Biomaterials 2008;1;250-62.
doi:10.1504/IJNBM.2008.016874
Hemmrich K, Van de Sijpe K, Rhodes NP, Hunt JA, di Bartolo C, Pallua N, Blondeel P, von Heimburg D. Autologous in vivo adipose tissue engineering in hyaluronan-based gels – a pilot study. Journal of Surgical Research 2008;144:82-8.
doi:10.1016/j.jss.2007.03.017
Hunt JA. Regenerative medicine: Materials in a cellular world. Nature Materials 2008;7:617-8.
doi:10.1038/nmat2242
Stillaert F, Hunt JA, Rhodes NP, Di Bartolo C, Tognana E, Monstrey S, Blondeel P. Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds. Biomaterials 2008;29:3953-9.
doi:10.1016/j.biomaterials.2008.06.005
Andrews KD, Feugier P, Black RA, Hunt JA. Vascular prostheses: performance related to cell-shear responses. Journal of Surgical Research 2008;149:39-46.
doi:10.1016/j.jss.2007.08.030
Hunt JA, Callaghan JT. Polymer-Hydroxyapatite composite versus polymer interference screws in anterior cruciate ligament reconstruction in a large animal model. Knee Surgery, Sports Traumatology, Arthroscopy 2008;16:655-60.
doi:10.1007/s00167-008-0528-8
Baldwin L, Hunt JA. The in vivo cytokine release profile following implantation. Cytokine 2008;41:217-22.
doi:10.1016/j.cyto.2007.11.015
Andrews KD, Hunt JA. Upregulation of matrix and adhesion molecules induced by controlled topography. Journal of Materials Science: Materials in Medicine 2008;19:1601-8.
doi:10.1007/s10856-008-3377-6
Andrews KD, Black RA, Hunt JA. The technology of electrostatic spinning for tissue engineering scaffolds. Polymer International 2008;57:203-10.
doi:10.1002/pi.2317
Richardson SM, Hughes N, Hunt JA, Freemont JA, Hoyland JA. Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials 2008;29:85-93.
doi:10.1016/j.biomaterials.2007.09.018

Rhodes NP. Inflammatory signals in the development of tissue-engineered soft tissue. Biomaterials 2007;28:5131-6.
doi:10.1016/j.biomaterials.2007.08.004

Hunt JA. The criticality of quantitative analysis and reproducibility for the development of interactive regenerative treatments. Biomaterials 2007;28:5128-30.
doi:10.1016/j.biomaterials.2007.07.016

Chen R, Hunt JA. Biomimetic materials processing for tissue-engineering processes. Journal of Materials Chemistry 2007;17:3974-9.
doi:10.1039/b706765h

Rhodes NP, di Bartolo C, Hunt JA. Analysis of the cellular infiltration of benzyl-esterified hyaluronan sponges implanted in rats. Biomacromolecules 2007;8:2733-8.
doi:10.1021/bm070368p

Rhodes NP, Wilson DJ, Williams RL. The effect of gas plasma modification on platelet and contact phase activation processes. Biomaterials 2007;28:4561-70.
doi:10.1016/j.biomaterials.2007.07.008

Tang ZG, Rhodes NP, Hunt JA. Control of the domain microstructures of PLGA and PCL binary systems: Importance of morphology in controlled drug release. Chemical Engineering Research & Design 2007;85:1044-50.
doi:10.1205/cherd06217

Mirsadraee S, Wilcox HE, Watterson KG, Kearney JN, Hunt JA, Fisher J, Ingham E. Biocompatibility of acellular human pericardium. Journal of Surgical Research 2007;143:407-14.
doi:10.1016/j.jss.2007.01.026

Oates M, Chen R, Duncan M, Hunt JA. The Angiogenic potential of three-dimensional open porous synthetic matrix materials. Biomaterials 2007;28:3679-86.
doi:10.1016/j.biomaterials.2007.04.042
  Andrews KD, Hunt JA, Black RA. Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds. Biomaterials 2007;28:1014-26.
doi:10.1016/j.biomaterials.2006.10.014

Brama M, Rhodes N, Hunt J, Ricci A, Teghil R, Migliaccio S, Della Rocca C, Leccisotti S, Lioi A, Scandurra M, De Maria G, Ferro D, Pu F, Panzini G, Politi L, Scandurra R. Effect of titanium carbide coating on the osseointegration response in vitro and in vivo. Biomaterials 2007;28:595-608.
doi:10.1016/j.biomaterials.2006.08.018

McGee A, Hunt JA. Bone regeneration in a bi-lateral sinus lift - A comparative pilot case study between irradiated human cancellous bone versus a synthetic analogue. European Journal for Dental Implantologists 2007;3:54-7.
Warde DM, Herrick SE, Hunt JA. Autologous fat transplantation and adipose tissue in tissue engineering. International Journal of Adipose Tissue 2007;1:42-8.
  Baldwin L, Hunt JA. Host inflammatory response to NiCr, CoCr, and Ti in a soft tissue implantation model. Journal of Biomedical Materials Research 2006;79:574-81.
doi:10.1002/jbm.a.30856
Curran JM, Chen R, Hunt JA. The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Biomaterials 2006;27:4783-93.
doi:10.1016/j.biomaterials.2006.05.001

Richardson SM, Walker RV, Parker S, Rhodes NP, Hunt JA, Freemont AJ, Hoyland JA. Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 2006;24:707-16. doi:10.1634/stemcells.2005-0205

Chen R, Curran SJ, Curran JM, Hunt JA. The use of poly(L-lactide) and RGD modified microspheres as cell carriers in a flow intermittency bioreactor for tissue engineering cartilage. Biomaterials 2006;27:4453-60.
doi:10.1016/j.biomaterials.2006.04.011

Tang ZG, Hunt JA. The effect of PLGA doping of polycaprolactone films on the control of osteoblast adhesion and proliferation in vitro. Biomaterials 2006;27:4409-18. doi:10.1016/j.biomaterials.2006.04.009
Richardson SM, Curran JM, Chen R, Vaughan-Thomas A, Hunt JA, Freemont AJ, Hoyland JA. The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-L-lactic acid (PLLA) scaffolds. Biomaterials 2006;27:4069-78.
doi:10.1016/j.biomaterials.2006.03.017
Fujiyoshi K, Hunt JA. The effect of particulate material on the regulation of chemokine receptor expression in leukocytes. Biomaterials 2006;27:3888-96.
doi:10.1016/j.biomaterials.2006.02.047
Rhodes NP, Bellón JM, Buján MJ, Soldani G, Hunt JA. Inflammatory response to a novel series of siloxane-crosslinked polyurethane elastomers having controlled biodegradation. Journal of Materials Science: Materials in Medicine 2005;16:1207-11.
doi:10.1007/s10856-005-4730-7
Marques AP, Reis RL, Hunt JA. The effect of starch-based biomaterials on leukocyte adhesion and activation in vitro. Journal of Materials Science: Materials in Medicine 2005;16:1029-43.
doi:10.1007/s10856-005-4757-9
Curran SJ, Chen R, Curran JM, Hunt JA. Expansion of human chondrocytes in an intermittent stirred flow bioreactor, using modified biodegradable microspheres. Tissue Engineering 2005;11:1312-22.
doi:10.1089/ten.2005.11.1312
Tang ZG, Callaghan JT, Hunt JA. The physical properties and response of osteoblasts to solution cast films of PLGA doped polycaprolactone. Biomaterials 2005;26:6618-24.
doi:10.1016/j.biomaterials.2005.04.013
Marques AP, Reis RL, Hunt JA. An in vivo study of the host response to starch-based polymers and composites subcutaneously implanted in rats. Macromolecular Bioscience 2005;5:775-85.
doi:10.1002/mabi.200500010

Curran JM, Chen R, Hunt JA. Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane-modified clean glass surfaces. Biomaterials 2005;26:7057-67.
doi:10.1016/j.biomaterials.2005.05.008

Hunt JA, Callaghan JT, Sutcliffe CJ, Morgan RH, Halford B, Black RA. The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration. Biomaterials 2005;26:5890-7.
doi:10.1016/j.biomaterials.2005.03.004
Al-Badairy H, Tatlock G, Fawcett S, Beahan P, Hunt J. FEG-SEM investigation of α-alumina scales formed on FeCrAlY alloys oxidised at 1200 °C. Journal of Physics IV France 2005;124:17-24.
doi:10.1051/jp4:2005124003
Baldwin L, Flanagan BF, Hunt JA. Flow cytometric measurement of phagocytosis reveals a role for C3b in metal particle uptake by phagocytes. Journal of Biomedical Materials Research 2005;73:80-5.
doi:10.1002/jbm.a.30252
Curran JM, Gallagher JA, Hunt JA. The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture. Biomaterials 2005;26:5313-20.
doi:10.1016/j.biomaterials.2005.01.065
Feugier P, Black RA, Hunt JA, How TV. Attachment, morphology and adherence of human endothelial cells to vascular prosthesis materials under the action of shear stress. Biomaterials 2005;26:1457-66.
doi:10.1016/j.biomaterials.2004.04.050
Rhodes NP. Biocompatibility testing of tissue engineered products. Vox Sanguinis 2004;87 Suppl 2:161-3.
doi:10.1111/j.1741-6892.2004.00477.x
Williams RL, Wilson DJ, Rhodes NP. Stability of plasma-treated silicone rubber and its influence on the interfacial aspects of blood compatibility. Biomaterials 2004;25:4659-73.
doi:10.1016/j.biomaterials.2003.12.010
Rhodes NP, Srivastava JK, Smith RF, Longinotti C. Heterogeneity in proliferative potential of ovine mesenchymal stem cell colonies. Journal of Materials Science: Materials in Medicine 2004;15:397-402.
doi:10.1023/B:JMSM.0000021109.21807.f0
Rhodes NP, Srivastava JK, Smith RF, Longinotti C. Metabolic and histological analysis of mesenchymal stem cells grown in 3-D hyaluronan-based scaffolds. Journal of Materials Science: Materials in Medicine 2004;15:391-5.
doi:10.1023/B:JMSM.0000021108.74004.7e
Smith P, Rhodes NP, Ke Y, Foster CS. Relationship between upregulated oestrogen receptors and expression of growth factors in cultured, human, prostatic stromal cells exposed to estradiol or dihydrotestosterone. Prostate Cancer and Prostatic Diseases 2004;7:57-62.
doi:10.1038/sj.pcan.4500692
Marques AP, Reis RL, Hunt JA. Cytokine secretion from mononuclear cells cultured in vitro with starch-based polymers and poly-L-lactide. Journal of Biomedical Materials Research 2004;71:419-29.
doi:10.1002/jbm.a.30155
Jackson PV, Hunt JA, Doherty PJ, Cannon A, Gilson P. Hydrophilicity of 3-D biomaterials: The Washburn equation. Journal of Materials Science: Materials in Medicine 2004;15:507-11.
doi:10.1023/B:JMSM.0000021129.60818.ca
Tang ZG, Black RA, Curran JM, Hunt JA, Rhodes NP, Williams DF. Surface properties and biocompatibility of solvent-cast poly[ ε-caprolactone] films. Biomaterials 2004;25:4741-8.
doi:10.1016/j.biomaterials.2003.12.003

Wilson DJ, Rhodes NP, Williams RL. Surface modification of a segmented polyetherurethane using a low-powered gas plasma and its influence on the activation of the coagulation system. Biomaterials 2003;24:5069-81.
doi:10.1016/S0142-9612(03)00423-X

Vallabhaneni SR, Gilling-Smith GL, Brennan JA, Heyes RR, Hunt JA, How TV, Harris PL. Can intrasac pressure monitoring reliably predict failure of endovascular aneurysm repair? Journal of Endovascular Therapy 2003;10:524-30.
doi:10.1583/1545-1550(2003)010<0524:CIPMRP>2.0.CO;2

Rice JM, Hunt JA, Gallagher JA, Hanarp P, Sutherland DS, Gold J. Quantitative assessment of the response of primary derived human osteoblasts and macrophages to a range of nanotopography surfaces in a single culture model in vitro. Biomaterials 2003;24:4799-818.
doi:10.1016/S0142-9612(03)00381-8

Alves CM, Reis RL, Hunt JA. Preliminary study on human protein adsorption and leukocyte adhesion to starch-based biomaterials. Journal of Materials Science: Materials in Medicine 2003;14:157-65.
doi:10.1023/A:1022023930825

Marques AP, Reis RL, Hunt JA. Evaluation of the potential of starch-based biodegradable polymers in the activation of human inflammatory cells. Journal of Materials Science: Materials in Medicine 2003;14:167-73.
doi:10.1023/A:1022028114896

Rice JM, Hunt JA, Gallagher JA. Quantitative evaluation of the biocompatible and osteogenic properties of a range of biphasic calcium phosphate (BCP) granules using primary cultures of human osteoblasts and monocytes. Calcified Tissue International 2003;72:726-36.
doi:10.1007/s00223-002-2045-y

Michanetzis GPA, Missirlis YF, Rhodes NP, Williams DF, Eloy R, Lemm W. Influence of test protocol in determining the blood response to model polymers. Journal of Materials Science: Materials in Medicine 2002;13:757-65.
doi:10.1023/A:1016166807299

Smith P, Rhodes NP, Ke Y, Foster CS. Upregulation of estrogen and androgen receptors modulate expression of FGF-2 and FGF-7 in human, cultured, prostatic stromal cells exposed to high concentrations of estradiol. Prostate Cancer and Prostatic Diseases 2002;5:105-10.
doi:10.1038/sj.pcan.4500571

Hunt JA, Shoichet MS. Biomaterials: drug delivery systems. Current Opinion in Solid State & Materials Science 2002;6:281.
doi:10.1016/S1359-0286(02)00115-8

Swindle EJ, Hunt JA, Coleman JW. A comparison of reactive oxygen species generation by rat peritoneal macrophages and mast cells using the highly sensitive real-time chemiluminescent probe Pholasin: inhibition of antigen-induced mast cell degranulation by macrophage-derived hydrogen peroxide. Journal of Immunology 2002;169:5866-73.

Pu FR, Williams RL, Markkula T, Hunt JA. Expression of leukocyte-endothelial cell adhesion molecules on monocyte adhesion to human endothelial cells on plasma treated PET and PTFE in vitro. Biomaterials 2002;23:4705-18.
doi:10.1016/S0142-9612(02)00219-3

Baldwin L, Flanagan BF, McLaughlin PJ, Parkinson RW, Hunt JA, Williams DF. A study of interface membranes from revision accord knee arthroplasty: the role of T lymphocytes. Biomaterials 2002;23:3007-14.
doi:10.1016/S0142-9612(02)00059-5

Pu FR, Williams RL, Markkula T, Hunt JA. Effects of plasma treated PET and PTFE on expression of adhesion molecules by human endothelial cells in vitro. Biomaterials 2002;23:2411-28.
doi:10.1016/S0142-9612(01)00377-5

Marques AP, Reis RL, Hunt JA. The biocompatibility of novel starch based polymers and composites: in vitro studies. Biomaterials 2002;23:1471-8.
doi:10.1016/S0142-9612(01)00272-1

Markkula TK, Hunt JA, Pu FR, Williams RL. Surface chemical derivatization of plasma-treated PET and PTFE. Surface and Interface Analysis 2002;34:583-7.
doi:10.1002/sia.1365

Pu FR, Williams RL, Markkula TK, Hunt JA. Monocyte adhesion and adhesion molecule expression on human endothelial cells on plasma-treated PET and PTFE in vitro. Journal of Materials Science: Materials in Medicine 2001;12:971-7.
doi:10.1023/A:1012861116388

Hunt JA, Shoichet M. Biomaterials: surface interactions. Current Opinion in Solid State & Materials Science 2001;5:161-2.
doi:10.1016/S1359-0286(01)00012-2

Hemingway R, Williams RL, Hunt JA, Rudge SJ. The influence of bracket type on the force delivery of Ni-Ti archwires. European Journal of Orthodontics 2001;23:233-41.
doi:10.1093/ejo/23.3.233

Smith P, Rhodes NP, Ke Y, Foster CS. Modulating effect of estrogen and testosterone on prostatic stromal cell phenotype differentiation induced by noradrenaline and doxazosin. Prostate 2000;44:111-7.
doi:10.1002/1097-0045(20000701)44:2<111::AID-PROS3>3.0.CO;2-3

Briggs MC, Grierson I, Hiscott P, Hunt JA. Active scatter factor (HGF/SF) in proliferative vitroretinal disease. Investigative Ophthalmology & Visual Science 2000;41:3085-94.

Davey PC, Zuzel M, Kamiguti AS, Hunt JA, Aziz KA. Activation-dependant proteolytic degradation of polymorphonuclear CD11b. British Journal of Haematology 2000;111:934-42.
doi:10.1111/j.1365-2141.2000.02401.x